At least two recent trials have suggested there may be a benefit to combining a dual-targeted approach with an aromatase inhibitor. Patients have different sensitivities to anti-HER2 agents, depending on whether they present with de novo metastases and thus have not received trastuzumab or they developed metastatic disease after adjuvant trastuzumab metastatic breast. JAMA Oncol 2: Trastuzumab in metastatic breast cancer after complete remission: The MARIANNE trial evaluated the benefit of pertuzumab added to ado-trastuzumab emtansine for first-line metastatic treatment, showing this combination was not more effective than trastuzumab metastatic breast emtansine alone.
2018 Treatment Algorithm for Metastatic HER2-Positive Breast Cancer
Some authors 2 raise questions about belief in the unavoidability of recurrence of metastatic breast cancer, specifically in the liver. In the second-line setting and beyond, in patients with prior exposure to trastuzumab, key trastuzumab made the following findings:. However, targeted treatment against the human metastatic breast growth factor receptor 2 her 2 significantly improves survival in patients with metastatic her 2-positive breast cancer, and some patients can respond with prolonged complete remissions.
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There are a few prognostic biomarkers, but no predictive ones, to guide the treatment selection of metastatic HER2 therapy. Abstract S On the other hand, some other trastuzumab metastatic breast were unable to identify any parameters useful in predicting long-term outcome 5. The MARIANNE trial evaluated the benefit of pertuzumab added to ado-trastuzumab emtansine for first-line metastatic treatment, showing this combination was not more effective than ado-trastuzumab emtansine alone.
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